Benjamin McMaster

This study evaluates AlphaFold 3's ability to predict T cell antigen specificity using structural models and finds that binding scores correlate with TCR positioning over pMHC, not chemical interactions.

This study quantifies conformational changes in the TCR:pMHC-I binding interface using a dataset of 358 structures, showing that CDR3 and CDR3β loops modify their shape upon binding and peptides undergo conformational changes dependent on their anchoring in the MHC groove.

The paper uses a computational model and experiments to show that small micro-patterned mPSC colonies exhibit spontaneous asymmetry in BRA-GFP patterns, suggesting a mechanism for symmetry-breaking in development.