Author

Joel Östblom

University of British ColumbiaORCID 0000-0003-0051-3239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Peter W. ZandstraiD· 4 shared Daniel Aguilar‐HidalgoiD· 3 shared Mukul TewaryiD· 3 shared M. Mona SiuiD· 2 shared Nicolas WerschleriD· 2 shared Tiam HeydariiD· 2 shared Alice VickersiD· 1 shared Andrew HagneriD· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersDevelopmental Biology

Peter W. ZandstraORCID

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4 papers

Recent·Most cited

Developmental BiologybioRxivPreprintDec 20, 2022

Symmetry-breaking in adherent pluripotent stem cell-derived developmental patterns

Daniel Aguilar‐Hidalgo, Joel Östblom, M. Mona Siu…·Peter W. Zandstra

The paper uses a computational model and experiments to show that small micro-patterned mPSC colonies exhibit spontaneous asymmetry in BRA-GFP patterns, suggesting a mechanism for symmetry-breaking in development.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

Developmental BiologyStem Cell ReportsPeer-reviewedNov 3, 2022

Gene regulatory network (GRN) embedded agents connect cellular decision making to human pluripotent stem cell derived germ layer-like pattern formation

Himanshu Kaul, Nicolas Werschler, Ross D. Jones…·Peter W. Zandstra

The paper develops a GRN model embedded in cellular agents to simulate hPSC lineage commitment and shows how GRN wiring influences germ layer pattern formation.

21 citations

humanbulk RNA-seq

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Developmental BiologyPLoS BiologyPeer-reviewedOct 21, 2019

High-throughput micro-patterning platform reveals Nodal-dependent dissection of peri-gastrulation-associated versus pre-neurulation associated fate patterning

Mukul Tewary, Dominika Dziedzicka, Joel Östblom…·Peter W. Zandstra

The paper develops an in vitro platform to study fate patterning in hPSCs, revealing Nodal-dependent switches between gastrulation and neurulation-associated gene profiles.

41 citations

humanbulk RNA-seq

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Systems BiologyMolecular Systems BiologyPeer-reviewedJan 1, 2018

MODELING SIGNALING-DEPENDENT PLURIPOTENT CELL STATES WITH BOOLEAN LOGIC CAN PREDICT CELL FATE TRANSITIONS

Ayako Yachie‐Kinoshita, Kento Onishi, Joel Östblom…·Peter W. Zandstra

The paper develops a computational model using Boolean logic to predict pluripotent stem cell fate transitions in response to signaling inputs.

57 citations

mousebulk RNA-seq

𝕏 PostBluesky