Christopher J. Thorpe

Characterising AlphaFold 3s ability to predict T cell antigen specificity

This study evaluates AlphaFold 3's ability to predict T cell antigen specificity using structural models and finds that binding scores correlate with TCR positioning over pMHC, not chemical interactions.

Reverse engineering the fatally cross-reactive A3A TCR to decouple potency and specificity

The paper reverse-engineers a TCR to reduce cross-reactivity while maintaining potency by reverting specific residues.

Early regional lymph node activation drives influenza vaccine responses in an ancestrally diverse cohort

This study examines immune responses in ancestrally diverse individuals after influenza vaccination, finding that draining lymph nodes show rapid activation and specific cellular changes.

Quantifying conformational changes in the TCR:pMHC-I binding interface

This study quantifies conformational changes in the TCR:pMHC-I binding interface using a dataset of 358 structures, showing that CDR3 and CDR3β loops modify their shape upon binding and peptides undergo conformational changes dependent on their anchoring in the MHC groove.