Sergio Ciordia

A generalizable normalization framework to decouple protocol and instrument effects: Application to high-sensitivity proteomics multicentric study (PME13)

This paper introduces a normalization framework to decouple protocol and instrument effects in multicenter proteomics studies, demonstrating its application to the PME13 dataset.

Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma

This study identifies altered epigenetic regulators and metabolic genes in cholangiocarcinoma, linking them to poor prognosis and metabolic-epigenetic crosstalk.

Multi-omics integrative approach of senescent endothelial cells and derived extracellular vesicles in a replicative senescence model

This study uses multi-omics profiling to characterize senescent endothelial cells and their EVs, identifying molecular signatures and regulatory networks involved in vascular aging and CVD.

Time-based quantitative proteomic and phosphoproteomic analysis of A549-ACE2 cells during SARS-CoV-2 infection

This study uses proteomics and phosphoproteomics to analyze A549-ACE2 cells during SARS-CoV-2 infection, identifying differentially expressed proteins and phosphorylation sites, and selecting serum biomarkers for COVID-19 prognosis.

Molecular basis of Progressive Familial Intrahepatic Cholestasis 3. A proteomics study.

This study identifies differentially expressed and phosphorylated proteins in PFIC3 liver samples and a murine model, revealing key cellular processes involved in disease progression.