Jihwan Park

This study shows T-cell immunological synaptosomes (TIS) reprogram APCs and induce durable anti-tumor immunity in a mouse model.

This study introduces scMnT, a method to quantify microsatellite instability (MSI) intensity at single-cell resolution in colorectal cancer, revealing heterogeneity and associations with immunotherapy response and cell origin.

The paper introduces Ouro-Seq, a long-read sequencing framework for full-length transcriptomes, and constructs a mouse splicing atlas revealing cell-type-specific splicing patterns.

This study uses single-cell RNA and ATAC sequencing to identify KLF2 as a key regulator of HIV-1 persistence and Th17 cell dysfunction in early infection.

The paper constructs a single-cell atlas of developing human brains to analyze the temporal and cellular specificity of neurological disorder genes across 393,060 cells.

The paper identifies molecular tension between phosphatidylserine and its receptors as a signal determining phagocytosis of apoptotic cells.

This study shows that Isl2 is essential for organizing motor pool position and sensorimotor circuits in hindlimb motor pools in mice.

The paper uses single-cell RNA sequencing to analyze diabetic cavernous tissues, identifying pericyte dysfunction and a novel marker LBH that promotes neurovascular regeneration.

The paper identifies potentially immunopathogenic SARS-CoV-2 epitopes using immunoinformatic methods and develops a web tool to visualize cross-reactive epitopes for vaccine design.

This study shows that Dnmt1 is critical for kidney development by maintaining methylation of transposable elements in Six2 progenitor cells, preventing their regression and ERV activation.

MuSiC deconvolves bulk RNA-seq data using single-cell RNA-seq reference to estimate cell type composition, outperforming existing methods in tissues with closely related cell types.

The paper uses allele-specific RNA imaging to show that allelic imbalances in tissues can result from transcriptional bursting and low mRNA abundance.

This study identifies 16 genome-wide significant loci associated with diabetic kidney disease, including a protective variant in the COL4A3 gene.