Yuting Guan

The paper identifies novel structural variants in Han Chinese genomes using long-read sequencing and links them to phenotypic diversity and disease susceptibility.

The paper identifies PTN secreted by fibroblasts acting on itself and macrophages via SDC4 in myocardial hypertrophy using scRNA-seq and experimental validation.

The paper maps genetic variants to cell types in the kidney to identify disease mechanisms and drug targets.

This study shows that Dnmt1 is critical for kidney development by maintaining methylation of transposable elements in Six2 progenitor cells, preventing their regression and ERV activation.