Author

Yuka Otsuka

The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & TechnologyORCID 0000-0003-3739-5790Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

Louis D. ScampaviaiD· 2 shared Thomas D. BannisteriD· 2 shared Timothy SpiceriD· 2 shared Bo Gao· 1 shared Brian S. AlejandroiD· 1 shared CG Teo· 1 shared Chao WangiD· 1 shared Charles C. BaileyiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Louis D. ScampaviaORCID

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3 papers

Recent·Most cited

MicrobiologyNature CommunicationsPeer-reviewedOct 27, 2026

A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation

Huihui Mou, Bo Gao, Gang Ye…·Hyeryun Choe

This paper describes a trimeric inhibitor, S22, that stabilizes the SARS-CoV-2 spike protein in a closed conformation, preventing ACE2 binding and viral entry.

DOI 10.1038/s41467-026-78835-9

humanstructural biology

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MicrobiologyPLoS PathogensPeer-reviewedApr 3, 2026

Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B

Donghoon Chung, Yuka Otsuka, Eunjung Kim…·Thomas D. Bannister

This paper identifies potent benzamide compounds against Zika virus by targeting NS4B, showing superior potency and novel resistance mutation patterns compared to existing treatments.

4 citationstop 1%

virusexperimental assay

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NeuroscienceeLifePeer-reviewedMay 10, 2023

Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons

Tetsushi Yamagata, Ikuo Ogiwara, Tetsuya Tatsukawa…·Kazuhiro Yamakawa

The paper confirms mutually exclusive Nav1.1 and Nav1.2 expression in neocortical neurons and identifies Nav1.1 expression in specific excitatory subpopulations.

22 citations

mouseexperimental assay

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