Author

Aditya Raguram

Broad InstituteORCID 0000-0002-5749-7308Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genomics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Hyewon Jang· 2 shared Adhiraj Goel· 1 shared Andrew T. Nelson· 1 shared Andrew V. AnzaloneiD· 1 shared Arnav Singh· 1 shared Carolline Rodrigues MenezesiD· 1 shared Christopher J. Podracky· 1 shared David R. LiuiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioengineering

Hyewon Jang

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintOct 5, 2026

Engineered mRNA-packaging virus-like particles enable efficient and precise mitochondrial base editing in vitro and in vivo

Hyewon Jang, Carolline Rodrigues Menezes, Krzysztof Palczewski, Aditya Raguram

This study develops mtBE-VLPs for transient mitochondrial base editing, achieving high efficiency and reduced off-target effects in vitro and in vivo.

DOI 10.64898/2026.10.04.756548

mousehuman

Synthetic BiologyNature CommunicationsPeer-reviewedApr 24, 2026

Genome-wide screening reveals producer-cell modifications that improve virus-like particle production and delivery potency

Diana Ly, Hyewon Jang, Adhiraj Goel…·Aditya Raguram

The paper identifies genetic modifications in producer cells that enhance virus-like particle production and delivery potency.

DOI 10.1038/s41467-026-71925-8

experimental assay

GenomicsbioRxivPreprintNov 1, 2021

Programmable large DNA deletion, replacement, integration, and inversion with twin prime editing and site-specific recombinases

Andrew V. Anzalone, Xin D. Gao, Christopher J. Podracky…·David R. Liu

This paper introduces twin prime editing (twinPE) and its combination with site-specific recombinases to enable precise DNA deletion, replacement, integration, and inversion in human cells without double-strand breaks.

16 citations

humanexperimental assay