Author

Janice A. Dominov

University of Massachusetts Chan Medical SchoolORCID 0000-0002-5751-0955Unclaimed ORCID profile · follow to get notified of new preprints

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1

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Alexander JaworskiiD· 1 shared Alexandra Weiss· 1 shared Alper KüçükuraliD· 1 shared Diane LipscombeiD· 1 shared Emma M. ShychuckiD· 1 shared Haruhiko BannoiD· 1 shared Hesheng ZhangiD· 1 shared John Page· 1 shared

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2023-2023 · peak 1/yr

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1 shared paperNeuroscience

Alexander JaworskiORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintMay 5, 2023

Up-regulation of cholesterol synthesis pathways and limited neurodegeneration in a knock-in Sod1 mutant mouse model of ALS.

Janice A. Dominov, Laura A. Madigan, Joshua P. Whitt…·Robert H. Brown

This study shows that Sod1G85R knock-in mice exhibit up-regulated cholesterol synthesis pathways and limited neurodegeneration, contrasting with severe TgSOD1G93A mice, suggesting lipid pathway dysregulation in ALS.

7 citations

mousebulk RNA-seq

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