Coordinate Up-regulation of Both TK1 and TS Expression in Cycling Cells: Mechanistic Basis and Implications for Dual-Targeted Cancer Therapy
Wanxing Wang, Jiawei Zhang, Guangyou Duan…·Gao Shan
The paper identifies coordinate up-regulation of TK1 and TS in cycling cells and shows it is essential for dTTP supply, supporting dual-targeted cancer therapy.