Xue Yao

The paper develops cell type-specific chromatin accessibility clocks using snATAC-seq data to predict age and detect aging-related changes in the brain.

The paper identifies coordinate up-regulation of TK1 and TS in cycling cells and shows it is essential for dTTP supply, supporting dual-targeted cancer therapy.

This study discovers a Notch/snRNA negative feedback regulation, linking cell signaling to RNA splicing and offering therapeutic implications for Alzheimer's disease.

This paper introduces a method to enhance two-photon optogenetic stimulation in live mouse brains by using fluorescent molecules to improve opsin activation efficiency.