Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma
Pauline Jeannot, Rebecca Rosberg, David Lindgren, John C. Dawson, Enrico Pracucci, Cornelia Börjesson Freitag, Julia Martinez, Vasiliki Pantazopoulou, Maria Malmberg, Karolina I. Smoląg, Dimitra Manou, Richard J. R. Elliott, Crister P Ceberg, Tracy J. Berg, Henrik Ahlenius, , Alexander Pietras
This paper identifies Flunarizine as a compound that inhibits radiation-induced astrocyte reactivity and improves survival in a glioblastoma model.
bioRxiv · Jul 12, 2025 · PreprintCancer Biology