‎Berend Snel

This study investigates the prokaryotic origins of eukaryotic genes related to metabolism and informational processing, revealing archaeal contributions to metabolic enzymes and lipid metabolism genes.

This study identifies 16 kinetochore proteins in Tetrahymena thermophila, revealing both conventional and unconventional components that contribute to its unique kinetochore structure.

The paper compares mutational profiles of natural, random, and de novo proteins to assess their structural robustness and evolutionary trajectories.

The paper investigates the evolutionary origins of central carbon metabolism in eukaryotes, revealing a chimeric gene repertoire with contributions from Asgardarchaeota and Alphaproteobacteria.

This study identifies RBM41 as a paralog of U11/U12-65K in the minor spliceosome, showing distinct roles in splicing and spliceosome dynamics.

The paper evaluates factors affecting protein interaction prediction using phylogenetic profiles in eukaryotes, finding that orthologous group and interactome selection have greater impact than genome selection.

This paper evaluates orthology methods by comparing their ability to recapitulate patterns of eukaryotic genome evolution, finding similar overall behavior but significant differences in inferred orthologous groups.

The paper identifies biallelic mutations in CENATAC as a cause of constitutional aneuploidy by disrupting minor intron splicing and causing chromosome segregation errors.

PhyRepID quantifies protein repeat evolution across 14 vertebrate species by detecting repeats, optimizing detection, and using phylogenetics to derive a PRD score for large-scale comparison.

The paper identifies a conserved motif cassette in BubR1 essential for the spindle checkpoint through phylogenomics and functional analysis.