Paulien Hogeweg

This paper develops a high-dimensional HIV-1 quasispecies model to predict viral rebound and guide antibody design without fitting to experimental data.

This study shows that biparental inheritance of endosymbionts during host-symbiont co-evolution leads to evolutionary conflict, which can be resolved through host regulation mechanisms, and that sexual reproduction may have emerged early in eukaryogenesis.

The paper compares mutational profiles of natural, random, and de novo proteins to assess their structural robustness and evolutionary trajectories.

The paper quantifies microbial niche breadth using environmental sequencing data, revealing generalist and specialist strategies across the tree of life.