Sandra Segura‐Bayona

This study shows TRF2 mediates force-resistant tethering of telomeric DNA repeats, which may be a step in T-loop formation.

The paper shows MEN1 deficiency reduces ferroptosis by altering ACSL1 and GPX4 levels, with selenite affecting resistance.

This study identifies distinct roles of ATRX in safeguarding genome and telomere integrity through interactions with CST and 9-1-1 complexes, revealing context-dependent mechanisms.

The paper identifies a covalent fragment inhibitor of TYMS that selectively kills ATRX-deficient cells through replication stress.

This paper identifies SLFN11's role in preventing alternative lengthening of telomeres by eliminating ATRX-deficient cells during telomere crisis, contributing to chemoresistance in cancer.

This study identifies SIRT1's role in regulating DNA damage signaling via interaction with the PP4 phosphatase complex, showing SIRT1 inhibits PP4 to modulate key DDR markers.

This study shows TLK1/2 activity protects replication forks, contributes to chromatin silencing, and suppresses innate immune responses, with implications for immune evasion in chromosomally unstable cancers.