Andrea Streit

The paper assesses axial patterning in human inner ear organoids and finds incomplete and disorganized regionalisation, suggesting limitations in self-organization and potential strategies to enhance cell complexity in vitro.

The paper integrates single-cell, spatial, and clonal data to study cranial placode development and evolution, revealing continuous transcriptional landscapes and shared progenitors between placodes.

The paper uses scATAC-seq to study chromatin accessibility changes during neural plate border cell fate specification, identifying new regulatory mechanisms involving Foxk2.

The paper uses single-cell RNA sequencing to study cell fate decisions at the neural plate border in chick ectoderm, proposing a gradient border model for fate allocation.

The paper constructs a gene regulatory network for neural induction using transcriptomics and epigenomics data, revealing 175 regulators and 5,614 interactions with temporal dynamics.

This study shows that Plzf coordinates the switch between early and late Fgf signalling regimes in the zebrafish hindbrain, ensuring proper segmentation and neurogenesis.

The paper identifies Sox8 as a key transcription factor that remodels cranial ectoderm to generate ear progenitors and activate ear development programs.

This study shows that CHD7 protects auditory neurons and hair cells from stress-induced degeneration, with implications for CHARGE syndrome.

This study shows PRDM1 regulates histone modifications to control the sequential activation of neural, neural crest, and sensory progenitor genes during early embryogenesis.

This study shows FGF signalling modifies chromatin landscape by promoting enhancer activation and acetylation, crucial for otic gene expression during ear progenitor induction.