This study uses whole genome sequencing to identify 18 novel genetic loci associated with plasma fibrinogen levels, including variants more common in African populations and linked to liver-related traits and disease.

Blood · Sep 3, 2024Peer-reviewedGenetic & Genomic Medicine

Antiviral Antibody Epitope Selection is a Heritable Trait

Thiagarajan Venkataraman, Cristian Valencia, Massimo Mangino, William R. Morgenlander, Steven J. Clipman, Thomas Liechti, Ana Valencia, Paraskevi Christofidou, Tim D. Spector, Mario Roederer, Priya Duggal, H. Benjamin Larman

The paper identifies heritable antibody epitopes and genetic loci associated with EBV immune responses and viral load control using twin and SNP-genotyped data.

bioRxiv · Mar 25, 2021 · PreprintGenetics

Within-sibship GWAS improve estimates of direct genetic effects

Laurence J Howe, Michel Guillaume Nivard, Tim Morris, Ailin Falkmo Hansen, Humaira Rasheed, Yoonsu Cho, Geetha Chittoor, Penelope A. Lind, Teemu Palviainen, Matthijs D. van der Zee, Rosa Cheesman, Massimo Mangino, Yunzhang Wang, Shuai Li, Lucija Klarić, , Neil M Davies

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

bioRxiv · Mar 5, 2021 · PreprintGenetics✦ In-depth digest

Large-scale genome-wide association meta-analysis of endometriosis reveals 13 novel loci and genetically-associated comorbidity with other pain conditions

Nilüfer Rahmioğlu, Banasik Karina, Paraskevi Christofidou, D. Larson Rebecca, Geneviève Galarneau, Giri Ayush, Stuart MacGregor, Sally Mortlock, Sapkota Yadav, Schork J Andrew, Marta Sobalska‐Kwapis, Lilja Stefansdottir, Turman Constance, Outi Uimari, Sosuke Adachi, , Hapangama K Dharani

This study identifies 13 novel genetic loci associated with endometriosis through a large GWAS meta-analysis and finds genetic links to other pain-related conditions.

bioRxiv · Sep 7, 2018 · PreprintGenomics