ImmunologybioRxivPreprint
Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly
Mikel D. Haggadone, Brian P. Goldspiel, Aoife O’Farrell…·Will Bailis
This study shows that environmental branched-chain amino acids regulate ASC translation and NLRP3 inflammasome assembly through mTOR-dependent translational bursting.