Crystal S. Conn

This study identifies ROR2 as a driver of right ventricular failure by disrupting proteostasis, showing that modulating ROR2 can rescue structural and functional deficits in cardiomyocytes.

This study identifies SPTBN2 as a regulator of immunosuppressive tumor microenvironment and cross-resistance to therapies, showing its role in suppressing CAR T-cell efficacy.

This study shows that environmental branched-chain amino acids regulate ASC translation and NLRP3 inflammasome assembly through mTOR-dependent translational bursting.

This study shows CD8+ T cells adapt to nutrient stress by reconfiguring gene-regulatory and metabolic networks, enabling functional resilience and anti-tumor immunity.