A targetable developmental program co-regulates angiogenesis and immune evasion
Pietro Berico, Amanda Flores Yanke, Fatemeh Vand-Rajabpour, Catherine Do, Irving Simonin Wilmer, Ines Delclaux, Tara Muijlwijk, Robert Stagnitta, Martha Estefania Vázquez‐Cruz, Theodore Sakellaropoulos, Matheus Ribeiro Costa, Annie Cristhine Moraes Sousa Squiavinato, Michelle Krogsgaard, Ata S. Moshiri, Iman Osman, , Eva Hernando
This study identifies HOXD13 as a driver of a developmental program in melanoma that promotes angiogenesis and suppresses T-cell infiltration through a gene regulatory axis involving VEGFA, SEMA3A, and CD73.
Cancer Discovery · Feb 3, 2026Peer-reviewedCancer Biology