Tara Muijlwijk

This study shows that lymph nodes actively drive melanoma evolution and immune evasion, linking regional metastasis to poor patient outcomes.

The paper identifies a lymphatic circuit that sustains stem-like CD8+ T cells by recycling tumor-experienced effector T cells, enhancing immune surveillance and ICB response.

This study shows that chromatin architecture and physical constriction together drive phenotype switching and metastasis in melanoma by altering CTCF positioning and heterochromatin structure.

This study identifies HOXD13 as a driver of a developmental program in melanoma that promotes angiogenesis and suppresses T-cell infiltration through a gene regulatory axis involving VEGFA, SEMA3A, and CD73.

This study identifies immune niches in NF1 mutant melanoma that promote immune evasion and shows EGFR inhibition can restore immune responses.