Author

Changjun Shao

Chinese Academy of SciencesORCID 0000-0002-5836-9447Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:variant calling· 3 Assay:whole-genome sequencing· 3 Research Focus:genome assembly· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:polygenic risk· 1

Frequent Co-Authors

Yanan ChuiD· 3 shared Jian Wang· 2 shared Jing CheniD· 2 shared Ran LiiD· 2 shared Shuming GuoiD· 2 shared Stylianos E. AntonarakisiD· 2 shared Yabin TianiD· 2 shared Yukun HeiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersGenomics

Yanan ChuORCID

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3 papers

Recent·Most cited

A T2T Benchmark Reveals How Reference Choice Shapes Human Genome Interpretation

Zhuo Huang, Yanan Chu, Yabin Tian, Changjun Shao, Jian Wang, Xueqi Zhang, Jing Chen, Zheng Jia, Lili Li, Jiale Li, Guigao Lin, Kuo Zhang, Stylianos E. Antonarakis, Yu Kang, Jie Huang

This paper benchmarks how reference genome choice affects human genome interpretation by comparing T2T references and finding ancestry-matched references provide more accurate variant discovery.

bioRxiv · Sep 10, 2026 · PreprintGenomics

Approaching an Error-Free Diploid Human Genome Using a Support-Based Validation Framework

Yanan Chu, Zhuo Huang, Changjun Shao, Shuming Guo, Yiji Yang, Xinyao Yu, Yurong Luo, Jian Wang, Yabin Tian, Jing Chen, Ran Li, Yukun He, Stylianos E. Antonarakis, Jun Yu, Jie Huang, , Yu Kang

The paper introduces a support-based validation framework to correct assembly errors in diploid genomes using independent sequencing evidence.

The Innovation · Aug 1, 2026Peer-reviewedGenomics

T2T-YAO: a Telomere-to-telomere Assembled Diploid Reference Genome for Han Chinese

Yukun He, Yanan Chu, Shuming Guo, Jiang Yong Hu, Ran Li, Yali Zheng, Xinqian Ma, Zhenglin Du, Lili Zhao, Wenyi Yu, Jianbo Xue, Wenjie Bian, Feifei Yang, Xi Chen, Pingan Zhang, , Zhancheng Gao

The paper presents T2T-YAO, a telomere-to-telomere diploid reference genome for a Han Chinese male, offering improved haplotype resolution and genetic diversity compared to T2T-CHM13.

Genomics Proteomics & Bioinformatics · Aug 16, 2023Peer-reviewedGenetics