Author

Guigao Lin

Chinese Academy of Medical Sciences & Peking Union Medical CollegeORCID 0000-0002-0406-9078Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1

Frequent Co-Authors

Kuo ZhangiD· 2 shared Yabin TianiD· 2 shared Zheng JiaiD· 2 shared Changjun ShaoiD· 1 shared Chentao YangiD· 1 shared Dongming FangiD· 1 shared Dongya WuiD· 1 shared Jiale Li· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenomics

Kuo ZhangORCID

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2 papers

Recent·Most cited

A T2T Benchmark Reveals How Reference Choice Shapes Human Genome Interpretation

Zhuo Huang, Yanan Chu, Yabin Tian, Changjun Shao, Jian Wang, Xueqi Zhang, Jing Chen, Zheng Jia, Lili Li, Jiale Li, Guigao Lin, Kuo Zhang, Stylianos E. Antonarakis, Yu Kang, Jie Huang

This paper benchmarks how reference genome choice affects human genome interpretation by comparing T2T references and finding ancestry-matched references provide more accurate variant discovery.

bioRxiv · Sep 10, 2026 · PreprintGenomics

Complete and haplotype-resolved maps of genomic and epigenetic discordance in monozygotic twins

Tengxue Lou, Dongming Fang, Guigao Lin, Zheng Jia, Yafang Qin, Yabin Tian, Lingxin Qiu, Xin Jin, Lei Cheng, Dongya Wu, Kuo Zhang, Chentao Yang, Jie Huang

The paper presents haplotype-resolved T2T assemblies of two MZ twins, revealing genomic and epigenetic divergence, including structural variation and DNA methylation differences.

bioRxiv · Oct 24, 2025 · PreprintGenomics