Heithem M. El‐Hodiri

Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells

This study shows S1P signaling regulates Müller glia dedifferentiation and neurogenesis in chick retinas through interactions with microglia and TGFβ/Smad3 signaling.

Ibudilast Protects Retinal Bipolar Cells from Excitotoxic Retinal Damage and Activates the mTOR Pathway

This study shows ibudilast protects retinal bipolar cells from excitotoxic damage by upregulating mTOR signaling and other pathways, with potential for clinical application.

Sphingosine-1-phosphate signaling through Müller glia regulates neuroprotection and the accumulation of immune cells in the rodent retina

This study shows that S1P signaling in Müller glia restricts immune cell accumulation, impairs neuron survival, and suppresses neurogenic reprogramming in damaged mouse retinas.

Protein phosphatases regulate the formation of Müller glia-derived progenitor cells in the chick retina

The paper investigates the role of protein phosphatases in regulating Müller glia reprogramming into progenitor cells in damaged chick retinas using scRNA-seq.

ID transcription factors regulate the ability of Muller glia to become proliferating neurogenic progenitor-like cells

This study shows ID transcription factors regulate Muller glia reprogramming into progenitor cells after retinal damage by controlling p21Cip1 levels and neurogenic potential.

Formation of Müller glia-derived progenitor cells in retinas depleted of microglia

The paper investigates how microglia depletion affects Muller glia-derived progenitor cell formation in chick retinas using scRNA-seq, identifying key signaling pathways involved.

Chromatin access regulates the formation of Muller glia-derived progenitor cells in the retina

This study shows that SAHH and HMTs regulate chromatin access in chick retinas to reprogram Muller glia into progenitor cells, but not in mouse retinas.

Fatty acid-binding proteins and fatty acid synthase influence glial reactivity and promote the formation of Müller glia-derived progenitor cells in the avian retina

This study investigates the role of fatty acid-binding proteins (FABPs) and fatty acid synthase (FASN) in glial reactivity and Müller glia-derived progenitor cell formation in the chick retina using scRNA-seq.

Nuclear Factor I in neurons, glia and during the formation of Muller glia-derived progenitor cells in avian, porcine and primate retinas

This study examines the expression patterns of Nuclear Factor I (NFI) isoforms in retinas of chick, pig, and monkey, finding that NFIA and NFIB are expressed in developing and mature retinal cells, with reduced levels in proliferating Muller glia-derived progenitor cells.