Andy J. Fischer

This study shows S1P signaling regulates Müller glia dedifferentiation and neurogenesis in chick retinas through interactions with microglia and TGFβ/Smad3 signaling.

This study shows ibudilast protects retinal bipolar cells from excitotoxic damage by upregulating mTOR signaling and other pathways, with potential for clinical application.

This study shows that S1P signaling in Müller glia restricts immune cell accumulation, impairs neuron survival, and suppresses neurogenic reprogramming in damaged mouse retinas.

The paper investigates the role of protein phosphatases in regulating Müller glia reprogramming into progenitor cells in damaged chick retinas using scRNA-seq.

This study shows ID transcription factors regulate Muller glia reprogramming into progenitor cells after retinal damage by controlling p21Cip1 levels and neurogenic potential.

The paper investigates how microglia depletion affects Muller glia-derived progenitor cell formation in chick retinas using scRNA-seq, identifying key signaling pathways involved.

This study shows that SAHH and HMTs regulate chromatin access in chick retinas to reprogram Muller glia into progenitor cells, but not in mouse retinas.

The paper investigates how different cytokines, growth factors, and damage paradigms affect NFkB signaling in mouse retinal Muller glia, showing activation varies with microglial involvement.

This study shows that NFkB signaling suppresses Müller glia-mediated neuron regeneration in the mammalian retina by promoting immune cell accumulation and inhibiting neurogenic potential.

This study investigates the role of fatty acid-binding proteins (FABPs) and fatty acid synthase (FASN) in glial reactivity and Müller glia-derived progenitor cell formation in the chick retina using scRNA-seq.

This study examines the expression patterns of Nuclear Factor I (NFI) isoforms in retinas of chick, pig, and monkey, finding that NFIA and NFIB are expressed in developing and mature retinal cells, with reduced levels in proliferating Muller glia-derived progenitor cells.

This study investigates the role of the endocannabinoid system in reprogramming Muller glia into progenitor cells in the retina, showing that eCB signaling promotes this process while suppressing NFkB activity in mouse Muller glia.

This study investigates MDK's role in retinal development and regeneration in chick and mouse, showing its impact on neuronal survival, glial reactivity, and Müller glia-derived progenitor cell formation.

This study identifies gene regulatory networks controlling proliferative and neurogenic competence in retinal Muller glia.

This study shows that NF-κB signaling suppresses Muller glia reprogramming into progenitor cells in the chick retina, with microglia modulating this effect.