BiochemistryProceedings of the National Academy of SciencesPeer-reviewed
Structural and Evolutionary Constraints of Organophosphate Resistance in Dipteran Carboxylesterases
Rebecca L. Frkic, Alex Giang, Sacha B. Pulsford…·Colin J. Jackson
This study investigates the molecular basis and evolutionary constraints of organophosphate resistance in dipteran carboxylesterases, revealing sequence context-dependent success of a mutation and trade-offs between affinity and turnover.
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