Author

Nicholas J Fraser

Australian National UniversityORCID 0000-0002-7326-0570Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Alex GiangiD· 1 shared Colin J. JacksoniD· 1 shared Davis H. Hopkins· 1 shared Jianwei LiuiD· 1 shared John Graham OakeshottiD· 1 shared Mojtaba EsmaeilyiD· 1 shared Paul D. Carr· 1 shared Peter D. MabbittiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Alex GiangORCID

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1 paper

Recent·Most cited

Structural and Evolutionary Constraints of Organophosphate Resistance in Dipteran Carboxylesterases

Rebecca L. Frkic, Alex Giang, Sacha B. Pulsford, Jianwei Liu, Mojtaba Esmaeily, Paul D. Carr, Nicholas J Fraser, Davis H. Hopkins, John Graham Oakeshott, Philip Batterham, Peter D. Mabbitt, Colin J. Jackson

This study investigates the molecular basis and evolutionary constraints of organophosphate resistance in dipteran carboxylesterases, revealing sequence context-dependent success of a mutation and trade-offs between affinity and turnover.

Proceedings of the National Academy of Sciences · Feb 23, 2026Peer-reviewedBiochemistry