Structural and Evolutionary Constraints of Organophosphate Resistance in Dipteran Carboxylesterases
Rebecca L. Frkic, Alex Giang, Sacha B. Pulsford, Jianwei Liu, Mojtaba Esmaeily, Paul D. Carr, Nicholas J Fraser, Davis H. Hopkins, John Graham Oakeshott, Philip Batterham, Peter D. Mabbitt, Colin J. Jackson
This study investigates the molecular basis and evolutionary constraints of organophosphate resistance in dipteran carboxylesterases, revealing sequence context-dependent success of a mutation and trade-offs between affinity and turnover.
Proceedings of the National Academy of Sciences · Feb 23, 2026Peer-reviewedBiochemistry