Cancer BiologybioRxivPreprint
Targeting proteasome composition reprograms tumor-intrinsic inflammation through selective degradation of STAT1
Merav D. Shmueli, Yongfeng Tao, Ekampreet Singh…·Yifat Merbl
This study identifies a small molecule targeting PSME4, which stabilizes STAT1 and reprograms tumor inflammation, suppressing tumor growth by altering cytokine signaling.
DOI 10.64898/2026.10.15.759172