Author

Mingliang Ye

Dalian Institute of Chemical PhysicsORCID 0000-0002-5872-9326Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Haiyang Zhu· 2 shared Keyun WangiD· 2 shared Lianji XueiD· 2 shared Biao YuiD· 1 shared Danni CaiiD· 1 shared Dian Yang· 1 shared G Y Liu· 1 shared Guangsen BaoiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

Haiyang Zhu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

AutoPELSA: an automated sample preparation system for proteome-wide identification of target proteins of diverse ligands

Lianji Xue, Xi Wang, Haiqian Yang, Jie Zhou, Hao Zhu, Jinhua Shen, Weina Gao, Ruijun Tian, Yan Wang, Mingliang Ye

AutoPELSA automates the PELSA workflow for proteome-wide ligand-protein interaction detection, enabling high-throughput analysis of both strong and low-affinity ligands.

Analytical Chemistry · Jun 29, 2026Peer-reviewedMolecular Biology

Neuromodulation of Foxp2+ hypothalamic neurons induces therapeutic hypothermia

Guangsen Bao, L Zhang, M M Li, Lu Wang, Ting Yu, Zewen Zhu, Jinghan Cui, Yunmei Zhu, Xiaofeng Lin, Jiayi Cong, G Y Liu, K. Dengke, Zhe Zhang, Mingliang Ye, Biao Yu, , Yongjun Dang

This study identifies Foxp2+ neurons in the medial preoptic area as a controllable node for inducing therapeutic hypothermia and demonstrates their antitumor effects.

bioRxiv · May 7, 2026 · PreprintNeuroscience

Detergent-Free Nuclear-Cytoplasmic Fractionation Enables Spatially Resolved PELSA for Enhanced Nuclear Drug Target Identification

Danni Cai, Kun Zou, Jiayi Wang, Haiyang Zhu, Yanni Ma, Jiayang Yan, Dian Yang, Xiaolei Zhang, Lijuan Zou, Keyun Wang, Mingliang Ye

This paper introduces a detergent-free nuclear-cytoplasmic fractionation method combined with PELSA to enhance detection of nuclear drug targets, showing improved identification of canonical and novel targets.

bioRxiv · Apr 13, 2026 · PreprintBiochemistry

PELSA-Decipher: a software tool for the processing and interpretation of ligand protein interaction dataset acquired by PELSA

Haiyang Zhu, Keyun Wang, Kejia Li, Zheng Fang, Jiahua Zhou, Lianji Xue, Mingliang Ye

PELSA-Decipher processes and interprets PELSA data to extract ligand-protein interaction details like binding proteins, sites, and affinities.

Journal of Proteome Research · Aug 14, 2025Peer-reviewedBioinformatics