K. Dengke

The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.

This study identifies Foxp2+ neurons in the medial preoptic area as a controllable node for inducing therapeutic hypothermia and demonstrates their antitumor effects.

The paper describes a reversible form of suspended animation in C. elegans induced by high population density and identifies molecular mechanisms regulating its induction and termination.

The paper introduces GENTIS, a genetically encoded ionic-stress sensor, and shows that proton accumulation drives sleep in C. elegans through v-ATPase inhibition and membrane disassembly.

This study identifies lipid metabolic reprogramming as a conserved mechanism conferring hypoxic and aging resilience in Arctic ground squirrels and C. elegans.

This study investigates the role of PATJ in cell stress responses and vascular remodeling after stroke using a mouse model and CRISPR-Cas9 knockout cells.

This study shows visible light affects behavioral memory and gene expression in C. elegans through a non-visual pathway involving cyp-14A5 and bZIP transcription factors.

This study shows that targeting the VHL-HIF axis suppresses mortality and cellular damage caused by APOE4 and other stressors in C. elegans and mice.

The paper identifies a nematode gene acquired via horizontal gene transfer from bacteria that enhances stress resilience by enabling L-rhamnose biosynthesis for cuticle integrity.

This study identifies a genetic pathway in C. elegans that detoxifies amygdalin by co-opting algal genes acquired via horizontal gene transfer.

This study shows that GPCR signaling in C. elegans promotes stress-induced organismic death through a genetic program involving ZIP-10 and lipid remodeling.

The study identifies TMEM132D's role in neuronal morphogenesis through interaction with NAP1 and the WAVE regulatory complex in C. elegans.

This study shows that MDT-15 regulates lipid composition and protein homeostasis to enable longevity at low temperatures in C. elegans.

The paper identifies a genetic pathway in C. elegans that mediates cold-warming response and promotes stress-induced phenoptosis through ZIP-10 regulation.

The paper identifies HIR-1 as a key receptor tyrosine kinase mediating cellular responses to hypoxia-induced ECM remodeling in C. elegans.