Mark Hintze

This study shows that HDAC1/2-mediated repression of Wnt receptors orients asymmetric division polarity in C. elegans seam cells by establishing positional cues.

The paper infers the core gene regulatory network governing seam cell development in C. elegans using smFISH data and computational models.

The paper shows that a single amino acid deletion in the heat shock protein HSP-110 in the C. elegans isolate CB4856 reduces the expressivity of a mutation in egl-18.

The paper shows that increased temperature causes a cell fate switch in C. elegans seam cells through changes in the Wnt asymmetry pathway, leading to symmetric cell divisions and increased seam cell numbers.

This study shows PRDM1 regulates histone modifications to control the sequential activation of neural, neural crest, and sensory progenitor genes during early embryogenesis.