DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint
Md Maruf Khan, Wynand Paul Roos, Charlotte R. Pearson, Stefan M. Leonard, Anusha Angajala, Denise Y. Gibbs, Jeffrey Liu, Camille C. Rose Ragin, Robert William Sobol
This study shows that DNA polymerase beta modulates the PARG-mediated replication checkpoint in HNSCC, and combining PARG and ATR/CHK1 inhibitors overcomes resistance.
DNA repair · Jun 1, 2025Peer-reviewedCancer Biology