Author

Olivia K. Ottone

Thomas Jefferson UniversityORCID 0000-0002-9044-1832Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:metabolomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

John A. Collins· 2 shared Makarand V. RisbudiD· 2 shared Qinglin Wu· 2 shared Amber Slaweski· 1 shared Bahiyah WatsoniD· 1 shared Boahen N. Kwakye· 1 shared Fatemeh NiaziorimiiD· 1 shared Jorge J. Mundo· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

John A. Collins

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2 papers

Recent·Most cited

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

Pranay L. Ramteke, Bahiyah Watson, Sanjana Jagannath, Sarah Elizabeth Bell, Mallory Toci, Olivia K. Ottone, Qinglin Wu, Oliver Abinader, Ramkrishna Mitra, John A. Collins, Ruteja A. Barve, Makarand V. Risbud

This study shows that activating SIRT6 with MDL-800 improves intervertebral disc health in aged mice by enhancing autophagy, reducing senescence, and improving matrix quality.

bioRxiv · Mar 5, 2026 · PreprintBiochemistry

Oral citrate supplementation mitigates age-associated pathological intervertebral disc calcification in LG/J mice

Olivia K. Ottone, Jorge J. Mundo, Boahen N. Kwakye, Amber Slaweski, John A. Collins, Qinglin Wu, Margery A. Connelly, Fatemeh Niaziorimi, Koen van de Wetering, Makarand V. Risbud

This study shows oral K3Citrate reduces disc calcification in LG/J mice without affecting bone structure or locomotion, suggesting Ca2+ chelation as a potential mechanism.

Aging Cell · Feb 11, 2025Peer-reviewedCell Biology