Elena Corujo-Simón

This study shows Wnt/β-catenin signalling promotes primitive endoderm (PrE) fate in mouse preimplantation embryos by working with FGF/ERK and regulating GATA6/GATA4 stability.

This study uses human naive PSC models to show FGF signaling is critical for hypoblast specification, revealing conservation with mouse lineage specification.

The paper introduces insideOutside, a method to classify interior and exterior cells in embryos using spatial data, showing improved accuracy over existing methods.

The paper identifies the sequential activation of hypoblast marker genes in the human blastocyst, supporting a model of sequential lineage commitment.

Entropy Sorting identifies meaningful cellular heterogeneity in scRNA-seq data, revealing the inner cell mass in human pre-implantation embryos.

The paper identifies dynamic cell surface fluctuations as a key factor in early embryonic lineage sorting, showing that increased surface fluctuations in primitive endoderm precursors drive their segregation from epiblast precursors.

The paper investigates how three-dimensional cell neighbourhoods in mouse blastocysts influence cell fate decisions by analyzing NANOG and GATA6 expression patterns.