Brian Hendrich

BCOR mutations establish a persistent culture-adaptive state in human induced pluripotent stem cells

This study identifies BCOR mutations in hiPSCs as a culture-adaptive state causing chromatin, transcriptomic, and proteomic changes, and develops a qPCR assay for detection.

Chromatin remodelling enables enhancer resetting to facilitate the ERK transcriptional response

The paper shows that chromatin remodelling by NuRD enables enhancer resetting in response to ERK signalling in mouse ES cells, facilitating a rapid and precise transcriptional response.

The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

This study identifies CHD4's role in restricting transcription factor binding to maintain regulatory function and silence cryptic enhancers.

Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells

The paper tracks SOX2 and NANOG dynamics in live cells using advanced microscopy and analysis pipelines, revealing differences in their spatiotemporal behavior due to protein-protein interactions.

HP1β and densely packed chromatin form separate microdomains in mouse ES cells, which are reconfigured upon exit from naive pluripotency

Enhancer-promoter interactions are reconfigured through the formation of long-range multiway chromatin hubs as mouse ES cells exit pluripotency

The paper studies 3D genome structure changes in single mouse ES cells exiting pluripotency, finding reorganization of enhancer-promoter interactions through multiway chromatin hubs.

The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells

This study shows NuRD complex coordinates gene expression during lineage commitment by reducing transcriptional noise, priming genes for activation, and maintaining stable states.

Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by NuRD

This study compares NuRD's role in human and mouse pluripotent stem cells, finding that NuRD is required for transcriptional responses to differentiation signals in both, but with distinct functional differences between species.

Subunit redundancy within the NuRD complex ensures fidelity of ES cell lineage commitment

The paper shows that MTA proteins in ES cell NuRD complex are functionally redundant, and NuRD is essential for maintaining differentiation trajectory during early lineage commitment.

Transcriptional control by Sall4 in blastocysts facilitates lineage commitment of inner cell mass cells

This study shows Sall4 maintains the gene regulatory network in ICM cells before lineage commitment, enabling efficient progression to epiblast or primitive endoderm.

The Nucleosome Remodelling and Deacetylation complex restricts Mediator access to enhancers to control transcription

This study shows the NuRD complex regulates enhancer chromatin structure and Mediator access to control transcription during lineage commitment in ES cells.

Mbd3 and deterministic reprogramming

The paper investigates the role of Mbd3 in reprogramming by examining its impact on pluripotency and differentiation in Mbd3-/- embryonic stem cells.