Ayelet T. Lamm

RNA binding by ADARs prevents RNA interference from attacking self-produced dsRNA

This study shows ADARs prevent RNAi from targeting self-produced dsRNA by reducing siRNA production and interfering with RNAi processing in C. elegans.

ADARs regulate cuticle collagen expression to promote survival to pathogen infection

This study shows that ADARs in C. elegans regulate cuticle collagen expression, enhancing survival to bacterial infections by maintaining physical barriers.

RESIC: A tool for comprehensive adenosine to inosine RNA Editing Site Identification and Classification

RESIC identifies and classifies A-to-I RNA editing sites across organisms and datasets, showing increased hyper-editing and ADAR1 activity in SARS-CoV-2 infected cells.

BiSEK: a platform for a reliable differential expression analysis

BiSEK improves differential expression analysis by identifying affected pathways without relying on individual gene significance, showing results relevant to FUBP1 depletion and SARS-CoV-2 infection.

Disruption in A-to-I editing levels affects C. elegans development more than a complete lack of editing

This study investigates the distinct roles of ADAR-1 and ADAR-2 in C. elegans by analyzing their effects on RNA editing, gene expression, and phenotypes when mutated individually.

QsRNA-seq: a method for high-throughput profiling and quantifying small RNAs

The paper introduces QsRNA-seq, a method for high-throughput profiling of small RNAs, showing it accurately quantifies miRNAs and identifies developmentally specific miRNAs in C. elegans.