Heather A. Hundley

RNA binding by ADARs prevents RNA interference from attacking self-produced dsRNA

This study shows ADARs prevent RNAi from targeting self-produced dsRNA by reducing siRNA production and interfering with RNAi processing in C. elegans.

ADARs mediate distinct RNA editing activity and gene regulation in the Caenorhabditis elegans germline

This study profiles A-to-I RNA editing activity in C. elegans germline and finds that ADARs have distinct roles compared to other tissues, with compensatory mechanisms buffering loss of function.

eIF4E assembly into C. elegans germ granules is essential for its repressive function

The paper shows that IFE-1 assembly into P granules is essential for its repressive function in C. elegans germ cells.

ADARs regulate cuticle collagen expression to promote survival to pathogen infection

This study shows that ADARs in C. elegans regulate cuticle collagen expression, enhancing survival to bacterial infections by maintaining physical barriers.

ADR-2 regulates fertility and oocyte fate in C. elegans

This study identifies ADR-2's role in regulating fertility and oocyte fate in C. elegans through RNA editing and genetic interactions with SQD-1.

ADARs employ a neural-specific mechanism to regulate PQM-1 expression and survival from hypoxia

The paper identifies a neural-specific post-transcriptional mechanism regulating PQM-1 expression and hypoxia survival through ADAR proteins in larval animals.

The RNA binding protein Swm is critical for Drosophila melanogaster intestinalprogenitor cell maintenance

This study shows that the RNA-binding protein Swm is essential for maintaining intestinal progenitor cell identity and function in Drosophila.

Disruption in A-to-I editing levels affects C. elegans development more than a complete lack of editing

This study investigates the distinct roles of ADAR-1 and ADAR-2 in C. elegans by analyzing their effects on RNA editing, gene expression, and phenotypes when mutated individually.