An epigenetic barrier sets the timing of human neuronal maturation
Gabriele Ciceri, Arianna Baggiolini, Hyunwoo Cho, Meghana Kshirsagar, Silvia K. Benito-Kwiecinski, Ryan M. Walsh, Kelly A. Aromolaran, Alberto J. Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J. Sevilla, Peter A. Goldstein, Joshua Levitz, Christina S. Leslie, , Lorenz Studer
Chromatin regulators including EZH2, EHMT1/2, and DOT1L establish an epigenetic barrier in human neural progenitors that poises maturation genes and sets the protracted pace of cortical neuron maturation.
Nature · Jan 31, 2024Peer-reviewedDevelopmental Biology✦ In-depth digest