Hermany Munguba

Stress-induced motivational impairment is marked by diminished frontocortical cellular communication and neuropeptide signaling

The paper identifies stress-induced changes in frontocortical cellular communication and neuropeptide signaling associated with motivational impairment in mice.

Toward a genetic signature of resistance to activity-based anorexia in striatal projecting cortical neurons

The paper identifies transcriptional differences in striatal projecting cortical neurons that distinguish rats susceptible from resistant to activity-based anorexia, linking gene expression patterns to metabolic and neural functions.

An epigenetic barrier sets the timing of human neuronal maturation

Chromatin regulators including EZH2, EHMT1/2, and DOT1L establish an epigenetic barrier in human neural progenitors that poises maturation genes and sets the protracted pace of cortical neuron maturation.

Projection-Targeted Photopharmacology Reveals Distinct Anxiolytic Roles for Presynaptic mGluR2 in Prefrontal- and Insula-Amygdala Synapses

The paper uses photopharmacology to show that mGluR2 in specific brain projections regulates distinct anxiety-related behaviors.

Combined small molecule treatment accelerates timing of maturation in human pluripotent stem cell-derived neurons

This study identifies a drug cocktail that accelerates maturation of hPSC-derived neurons and other cell types through pharmacological intervention.

Psilocybin prevents activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms.

This study shows psilocybin improves cognitive flexibility and body weight in female rats with activity-based anorexia, mediated by 5-HT1A and 5-HT2A receptor mechanisms.

Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration

This study investigates the role of Sox6 in maintaining somatostatin interneuron subtype identity during migration, finding that its removal reduces subtype diversity in the mature cortex.

Activin receptor ALK4 coordinates extracellular signals and intrinsic transcriptional programs to regulate development of cortical somatostatin interneurons

This study shows that ALK4 signaling integrates extracellular signals with intrinsic transcriptional programs to regulate the development of somatostatin interneurons in the cortex.

Single-cell transcriptomic profiling of progenitors of the oligodendrocyte lineage reveals transcriptional convergence during development

The paper uses single-cell transcriptomics to show that embryonic Pdgfra+ cells give rise to OPCs with convergent transcriptional profiles in different CNS regions.