Ryan M. Walsh

This paper presents a protocol to rapidly generate human oligodendrocytes from pluripotent stem cells using BMP and Notch signaling inhibition, achieving high purity and functional myelination.

This study improves the yield and subtype identity of hPSC-derived midbrain dopamine neurons through optimized WNT and FGF18 signaling modulation, enhancing their functional and transcriptional similarity to primary neurons.

The paper develops a cortical assembloid system to study human PVALB+ interneuron development and identifies schizophrenia-associated defects in their migration and molecular profiles.

This study generates human cerebral organoids with a structured outer subventricular zone by activating the STAT3 pathway with LIF, mimicking in vivo oRG development and enhancing neuronal maturation.

Chromatin regulators including EZH2, EHMT1/2, and DOT1L establish an epigenetic barrier in human neural progenitors that poises maturation genes and sets the protracted pace of cortical neuron maturation.

This study identifies a drug cocktail that accelerates maturation of hPSC-derived neurons and other cell types through pharmacological intervention.