Ultra-slow conformational dynamics and catch bond formation of a Bacterial Adhesin revealed by a single-domain variant of FimH.
Pearl Magala, Lisa M. Tuttle, Gianluca Interlandi, Laura A. Carlucci, Molly Y. Mollica, Maria K. Janowska, Wendy E. Thomas, Evgeni V. Sokurenko, Rachel E. Klevit
This study investigates FimH conformational dynamics and catch bond formation using a single-domain variant, revealing ultra-slow dynamics and a dynamic allosteric mechanism.
Proceedings of the National Academy of Sciences · May 27, 2026Peer-reviewedBiochemistry