Author

Jeffrey D. Messinger

University of Alabama at BirminghamORCID 0000-0002-5975-3862Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Mai NguyeniD· 2 shared Steven J. PittleriD· 2 shared Christianne E. StrangiD· 1 shared Christine A. CurcioiD· 1 shared David M. SherryiD· 1 shared Delores A. StacksiD· 1 shared Dibyendu ChakrabortyiD· 1 shared Dwight E. Stambolian· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Mai NguyenORCID

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Author profile →

3 papers

Recent·Most cited

Selective Knockout of Murine Glutamic Acid-rich Protein 2 (GARP2) Significantly Alters Cellular Dark Noise in Rod Photoreceptors

Delores A. Stacks, Ulisse Bocchero, Marci L. DeRamus, Mai Nguyen, Jeffrey D. Messinger, Timothy W. Kraft, Steven J. Pittler, Johan Pahlberg

This study knocks out GARP2 in mouse rods and finds it reduces dark noise through PDE6 stabilization, affecting rod function without major structural changes.

bioRxiv · May 9, 2025 · PreprintNeuroscience

Modeling Retinitis Pigmentosa 59: Dhdds T206A and Dhdds K42E knock-in mutant mice are phenotypically similar.

Mai Nguyen, Dibyendu Chakraborty, Jeffrey D. Messinger, David M. Sherry, Steven J. Fliesler, Steven J. Pittler

This study generates and compares T206A and K42E Dhdds mutant mice to model RP59, finding similar retinal degeneration phenotypes despite different mutation combinations.

bioRxiv · Jan 13, 2025 · PreprintCell Biology

Integrative single-cell and bulk RNA-seq analysis in human retina identified cell type-specific composition and gene expression changes for age-related macular degeneration

Yafei Lyu, Randy J. Zauhar, Nico Dana, Christianne E. Strang, Kui Wang, Shanrun Liu, Zhen Miao, Naifei Pan, Paul D. Gamlin, James A. Kimble, Jeffrey D. Messinger, Christine A. Curcio, Dwight E. Stambolian, Mingyao Li

The paper uses single-cell and bulk RNA-seq to analyze gene expression changes in human retina with AMD, identifying cell type-specific alterations.

bioRxiv · Sep 14, 2019 · PreprintGenomics