Author

Dwight E. Stambolian

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 4

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ATAC-seq· 1 Research Focus:batch correction / integration· 1

Frequent Co-Authors

Kui WangiD· 2 shared Margaret M. DeAngelisiD· 2 shared Mingyao LiiD· 2 shared Sarah Xin ZhangiD· 2 shared Yafei LyuiD· 2 shared Ahmed H. GhobashiiD· 1 shared Ajith V. PankajamiD· 1 shared Akbar Shakoor· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersGenomics

Kui WangORCID

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4 papers

Recent·Most cited

An Integrated Multi-omics Single Cell Atlas of the Human RPE and Choroid

Jianming Shao, Xuan Bao, Ismail Yaman, Y Zheng, Jun Wang, Jin Li, Tingting Yang, Jinjing Jian, Jean Li, Seth Blackshaw, Kapil Bharti, Margo S. Clarke, Dwight E. Stambolian, C Sung, Jie Zheng, , Rui Chen

The paper constructs a multi-omics single-cell atlas of human RPE and choroid, identifying cell types, aging patterns, and genetic risk factors for AMD.

bioRxiv · Jul 24, 2026 · PreprintGenomics

Patterns of gene expression and allele-specific expression vary among macular tissues and clinical stages of Age-related Macular Degeneration

Treefa Shwani, Charles Zhang, Leah A. Owen, Akbar Shakoor, Albert T. Vitale, John H. Lillvis, Julie L. Barr, Parker Cromwell, Robert C. Finley, Nadine J. Husami, Elizabeth D. Au, Rylee A. Zavala, Elijah C. Graves, Sarah Xin Zhang, Michael H. Farkas, , Margaret M. DeAngelis

This study identifies differentially expressed genes and allele-specific expression in macular tissues across AMD stages, highlighting the RPE/choroid's role in disease pathophysiology.

Cells · Nov 21, 2023Peer-reviewedGenomics

Deep learning enables accurate clustering and batch effect removal in single-cell RNA-seq analysis

Xiangjie Li, Kui Wang, Yafei Lyu, Huize Pan, Jingxiao Zhang, Dwight E. Stambolian, Katalin Suszták, Muredach P. Reilly, Gang Hu, Mingyao Li

This paper introduces DESC, a deep learning method for single-cell clustering that improves accuracy and removes batch effects.

Nature Communications · May 11, 2020Peer-reviewedGenomics

Integrative single-cell and bulk RNA-seq analysis in human retina identified cell type-specific composition and gene expression changes for age-related macular degeneration

Yafei Lyu, Randy J. Zauhar, Nico Dana, Christianne E. Strang, Kui Wang, Shanrun Liu, Zhen Miao, Naifei Pan, Paul D. Gamlin, James A. Kimble, Jeffrey D. Messinger, Christine A. Curcio, Dwight E. Stambolian, Mingyao Li

The paper uses single-cell and bulk RNA-seq to analyze gene expression changes in human retina with AMD, identifying cell type-specific alterations.

bioRxiv · Sep 14, 2019 · PreprintGenomics