Cancer BiologyPNAS NexusPeer-reviewed
Ancient and Animal-Specific Regulatory Modes of EWS::FLI1 Revealed by a Minimal Yeast Model.
Diego Velázquez, Cristina Molnar, José Reina…·Cayetano González
This paper shows EWS::FLI1 can activate GGAASat sequences into enhancers in yeast, suggesting this function is ancient, while broader transcriptome changes require animal-specific factors.