Diane C. Saunders

This study demonstrates that AAV-DJ efficiently and safely transduces human ovarian cells, enabling targeted gene modulation with significant knockdown of AMHR2 and TGF{beta}1.

The paper maps the morphological and functional maturation of human endocrine pancreas from birth to age 10 using pediatric tissue samples and imaging techniques.

In 299 islet preparations from donors without diabetes, endocrine cell composition, not donor demographics, tracked insulin secretion, and δ cell percentage rose with type 2 diabetes genetic risk.

CelLink integrates single-cell multi-omics data by addressing weak feature linkage and imbalanced cell populations, outperforming existing methods in imputation accuracy and cell subtype annotation.

AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics data, showing improved performance over existing methods in diabetic tissue analysis.

The paper identifies combinatorial transcription factor expression in human islet cells and shows it correlates with functional maturity and electrophysiological activity.