The paper investigates a CRF circuit from the dorsal raphe to the basolateral amygdala that regulates cocaine-memory reconsolidation through DREADD-mediated manipulation and behavioral assays.

8 citations

ratexperimental assay

𝕏 PostBluesky

NeuroscienceNeuropsychopharmacologyPeer-reviewedMay 17, 2022

Optogenetic inhibition of the dorsal hippocampus CA3 region during early-stage cocaine-memory reconsolidation disrupts subsequent context-induced cocaine seeking in rats

Shuyi Qi, Shi Min Tan, Rong Wang…·Rita A. Fuchs

19 citations

ratexperimental assay

𝕏 PostBluesky

NeuroscienceNeuropsychopharmacologyPeer-reviewedJan 15, 2021

Basolateral amygdala CB1 receptors modulate HPA axis activation and context-cocaine memory strength during reconsolidation

Jessica A. Higginbotham, Nicole M. Jones, Rong Wang…·Rita A. Fuchs

The paper investigates the role of BLA CB1R in cocaine-memory reconsolidation and its impact on context-induced cocaine-seeking behavior and HPA axis activation.

20 citations

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceJournal of NeurosciencePeer-reviewedNov 30, 2020

CB1 receptor signaling modulates amygdalar plasticity during context-cocaine memory reconsolidation to promote subsequent cocaine seeking

Jessica A. Higginbotham, Rong Wang, Ben D. Richardson…·Rita A. Fuchs

This study shows that blocking CB1R during cocaine memory reconsolidation reduces cocaine-seeking behavior and alters synaptic plasticity in the basolateral amygdala.

25 citations

ratexperimental assay

𝕏 PostBluesky

NeuroscienceJournal of NeurosciencePeer-reviewedJan 17, 2020

Vaporized cannabis extracts have reinforcing properties and support conditioned drug-seeking behavior in rats

Timothy G. Freels, Lydia N. Baxter-Potter, Janelle M. Lugo…·Ryan J. McLaughlin

This study shows that vaporized THC-rich cannabis extracts reinforce behavior and increase drug-seeking in rats, supporting their use as a preclinical model for cannabis research.

107 citationstop 1%

ratexperimental assay

𝕏 PostBluesky