Jessica A. Higginbotham

Development and pharmacological evaluation of an intranasal liposomal norbinaltorphimine formulation for the prevention of pain-induced negative affect

This paper develops an intranasal liposomal NorBNI formulation that selectively delivers KOR antagonists to the brain, reducing systemic exposure and off-target effects while improving pain-induced negative affect.

Environmental Enrichment Attenuates Fentanyl-Seeking Behavior and Protects Against Stress-Induced Reinstatement in Both Male and Female Rats

This study shows that object-based environmental enrichment reduces fentanyl intake and stress-induced relapse in rats, suggesting it could be a scalable intervention for opioid use and relapse prevention.

Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive behavior

This study shows that peripheral opioid receptor antagonism can reverse fentanyl-induced respiratory depression without causing aversive behaviors.

Time-dependent enhancement in ventral tegmental area dopamine neuron activity drives pain-facilitated fentanyl intake in males

The paper shows that pain increases fentanyl self-administration in male rats through time-dependent changes in ventral tegmental area dopamine neuron activity.

Optogenetic inhibition of the dorsal hippocampus CA3 region during early-stage cocaine-memory reconsolidation disrupts subsequent context-induced cocaine seeking in rats

Basolateral amygdala CB1 receptors modulate HPA axis activation and context-cocaine memory strength during reconsolidation

The paper investigates the role of BLA CB1R in cocaine-memory reconsolidation and its impact on context-induced cocaine-seeking behavior and HPA axis activation.

CB1 receptor signaling modulates amygdalar plasticity during context-cocaine memory reconsolidation to promote subsequent cocaine seeking

This study shows that blocking CB1R during cocaine memory reconsolidation reduces cocaine-seeking behavior and alters synaptic plasticity in the basolateral amygdala.