Author

Yijie Shen

Shanghai Medical College of Fudan UniversityORCID 0000-0002-6700-9902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Jia FaniD· 2 shared Qin Feng· 2 shared Ruijie GongiD· 2 shared Songchen Liu· 2 shared Xianjiang LaniD· 2 shared Chuxuan Peng· 1 shared Fei LaniD· 1 shared Jia Yu· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Jia FanORCID

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2 papers

Recent·Most cited

Dual function of DOT1L suppresses tumor intrinsic immunogenicity in hepatocellular carcinoma

Siyuan Xu, Ruijie Gong, Songchen Liu, Jianhua Wang, Yijie Shen, Chuxuan Peng, Qin Feng, Min Luo, Fei Lan, Jia Fan, Jiabin Cai, Xianjiang Lan

The paper identifies DOT1L as a suppressor of tumor intrinsic immunogenicity using CRISPR screens and shows its inhibition enhances immune response in mice.

Oncogene · Mar 30, 2026Peer-reviewedCell Biology

BRD8 Disruption Unlocks Retrotransposon-Driven Tumor-Intrinsic Immunogenicity via Redistribution of Histone Acetylation in Liver Cancer

Ruijie Gong, Yijie Shen, Jianhang Huang, Jie Wang, Siyuan Xu, Songchen Liu, Qin Feng, Jia Yu, Jianing Zhao, Jia Fan, Jiajun Cai, Xianjiang Lan

This study identifies BRD8 as an epigenetic suppressor of tumor-intrinsic immunity in liver cancer, showing its depletion enhances immunogenicity and sensitizes tumors to immunotherapy.

bioRxiv · Jan 23, 2026 · PreprintCancer Biology