BRD8 Disruption Unlocks Retrotransposon-Driven Tumor-Intrinsic Immunogenicity via Redistribution of Histone Acetylation in Liver Cancer
Ruijie Gong, Yijie Shen, Jianhang Huang, Jie Wang, Siyuan Xu, Songchen Liu, Qin Feng, Jia Yu, Jianing Zhao, Jia Fan, Jiajun Cai, Xianjiang Lan
This study identifies BRD8 as an epigenetic suppressor of tumor-intrinsic immunity in liver cancer, showing its depletion enhances immunogenicity and sensitizes tumors to immunotherapy.
bioRxiv · Jan 23, 2026 · PreprintCancer Biology